Manual Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology

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    Skeletal Aging and Osteoporosis

    Cowin, Boca Raton, Fla. Reich MS, Akkus O, Sporicidal efficacy of genipin: a potential theoretical alternative for biomaterial and tissue graft sterilization, Cell and Tissue Banking, in revision. Akhilesh K. Uquillas J. Kishore, V. Biomaterials, 33 7 , Uquillas JA, Kishore V and Akkus O, Effects of phosphate-buffered saline concentration and incubation time on the mechanical and structural properties of electrochemically aligned collagen threads, Biomedical Materials, Volume 6, Issue 3, Jun;7 6 Gaharwar AK, Schexnailder P.

    Cheng X.

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    Gursel, I. Komurcu, M. Xu, X. Sun, J. Liu, Q. Song, M.

    Introduction

    Muckley, O. Akkus, and Y.

    Kim, "Spectroscopic visualization of nanoscale deformation in bone: interaction of light with partially disordered nanostructure", Journal of Biomedical Optics, 15 6 , Song, S. Xiao, Z. Xu, J. Liu, X. Sun, V. Drachev, V. Shalaev, O. This information can then be used during the planning stages to focus in vivo studies on only the relevant experiments, and also to minimise the number of animals required within the study.

    Our publications

    In order to develop new and adequate treatments for osteoporotic fracture fixation, it is essential to better understand the process of bone regeneration following implant placement in osteoporotic bone which have undergone treatment. In this project, we developed a novel method to assess time-lapsed bone response following implantation and to analyze the effect of applied treatment in a mouse model of osteoporosis.

    Successful fracture repair highly depends on the local mechanical conditions in the fracture area and adequate mechanical stimuli can actually improve and fasten the healing process. However, the underlying molecular mechanisms are still poorly understood.

    By combining state-of-the-art in vivo imaging with single cell analysis, this study aims to better understand mechanically-induced cellular and molecular signaling discriminating successful versus impaired healing conditions. It is important to understand the protein expression of the 3D osteocyte network in relation to the local bone environment.

    This understanding will have important implications for the identification of clinical targets for bone disease such as osteoporosis. In this project, a novel methodological platform known as LivE imaging, which was previously developed within the group, is being expanded and optimised to incorporate 3D data sets. This will allow the remodelling activity of the osteocyte network to be linked to protein expression patterns under a range of conditions. High-resolution in vivo images of the bone combined with other clinical measurements potentially allows to improve health and disease prognosis.

    In this project, we are aiming at developing in silico prognosis methods to predict medical outcomes, for example, simulating the effects of certain treatment options virtually in the patient. Bone is constantly undergoing adaptations in bone mass and shape, also called bone remodelling.

    Studies in Mechanobiology, Tissue Engineering and Biomaterials | yvoropijajif.gq

    Three different types of bone cells osteocytes, osteoblasts and osteoclasts are known to orchestrate the process of bone remodelling. Detailed information about cell-related biomechanical processes regulating bone remodelling could reveal potential targets for the prevention and treatment of bone diseases like osteoporosis in the future. The technique of micro-computed tomography micro-CT provides three-dimensional images of internal structures of objects in the micrometre range non-destructively. The morphometry of these objects can be further evaluated by the application of image-processing algorithms to assess structural indices like object volume, surface, porosity, pore diameters and many more.

    Due to the non-destructive nature of micro-CT individual samples can be monitored longitudinally over time. Micro-CT is particularly used in the bone field to due to the excellent contrast of bone tissue to soft tissue, but it can be applied to many other structures as well. Homepage Navigation Content Sitemap Search. The Group.

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