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Direct injection of TNF in sensitized mice results in large scale hepatocyte apoptosis which is exclusively and selectively mediated by the kDa TNF-R. Fulminant apoptotic liver damage is also triggered upon stimulation of CD Possible triggering cells include hepatocytes that express CD95L under pathological conditions. Despite the lack of interaction between TNF-R and CD95 on the receptor level, their signal transduction inside the cell seems to involve common proteolytic steps since inhibition of proteases of the caspase family blocks hepatocyte death, liver damage, or lethality in mice signaled by either receptor.

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Cytokine-Mediated Hepatic Apoptosis

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    Reviews of Physiology, Biochemistry and Pharmacology 158

    National Center for Biotechnology Information, U. National Library of Medicine. Trends Neurosci.


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      I. Introduction

      Genome Res. Ion channel , cell surface receptor : ligand-gated ion channels. Categories : Genes on human chromosome 8 Ion channels Nicotinic acetylcholine receptors Membrane protein stubs.