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PLoS One ;8:e A diagnostic assay based on microRNA expression accurately identifies malignant pleural mesothelioma. J Mol Diagn ; Repertoire of human natural anti-glycan immunoglobulins.

Malignant Mesothelioma

Do we have auto-antibodies? Biochim Biophys Acta ; Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma. N Engl J Med ; Clinical utility of liquid-chromatographic analysis of effusions for hyaluronate content. Clin Chem ; Diagnostic value of fluorescence in situ hybridization assay in malignant mesothelioma: A meta-analysis. Asian Pac J Cancer Prev ; Adell E, Dejmek A. Telomerase activity analyzed with TRAP in situ provides additional information in effusions remaining equivocal after immunocytochemistry and hyaluronan analysis.

Diagn Cytopathol ;42 12 Zendehrokh N, Dejmek A. Telomere repeat amplification protocol TRAP in situ reveals telomerase activity in three cell types in effusions: Malignant cells, proliferative mesothelial cells, and lymphocytes.


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Adaptation of a commercial fluorescent in situ hybridization test to the diagnosis of malignant cells in effusions. Pleural fluid cytological yield and visceral pleural invasion in patients with epithelioid malignant pleural mesothelioma. J Thorac Oncol ; CytoJournal ; Table 1: Cytomorphological criteria indicating malignancy Click here to view.

Figure 1: Effusions with epithelioid mesothelioma. Figure 2: Cytomorphology of epithelioid mesothelioma cells and tissue fragments in effusions. The tissue fragments sometimes show gaps or windows, a and b occur both as spheres with smooth surfaces c and d and in berry-like clusters with scalloped surface e and f. Figure 3: Cytomorphology of the epithelioid mesothelioma cells in effusions. The malignant mesothelioma cells often show macronucleoli.

Table 2: Summary of cytomorphological criteria indicating malignant mesothelioma [cf. Figures ] Click here to view.

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Figure 4: Immunohistochemical and immunocytochemical reactivities of malignant mesothelioma MM cells as seen in cell blocks first and third column and cytospin preparations second and fourth column. Epithelial membrane antigen and D positivity is accentuated at the cell membrane, while specific WT1 reactivity is nuclear.

Figure 5: The use of double stainings. Cytospin preparations double-stained for BerEp4 brown and calretinin red; left column and desmin brown and epithelial membrane antigen red; right column are useful to distinguish malignant mesothelioma MM from both adenocarcinomas and reactive mesothelial cell proliferations. In MM samples the tumour cells show dominant reactivity to Calretinin and epithelial membrane antigen a and b , while reactive benign mesothelial cells reacts to calretinin and desmin c and d.

Foto: AH Click here to view. Figure 6: Diagnostic markers used in the differential diagnosis between diffuse malignant peritoneal mesothelioma DMPM and serous carcinoma. Figure 7: Electron microscopy of malignant mesothelioma MM in effusions. Figure 3 g] Click here to view. The epidemiology of mesothelioma [review]. Semin Oncol. Malignant pleural mesothelioma. Ann Oncol. Benign and malignant pleural mesothelioma.

Clin Chest Med. Benign localized mesothelioma of the pleura. Cullen MR. Controversies in asbestos-related lung cancer. Occup Med.


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  • Malignant mesothelioma. Br J Cancer. May Rusch VW. Clinical features and current treatment of diffuse malignant pleural mesothelioma. Lung Cancer. Diffuse malignant mesothelioma.

    Mesothelioma: Treatment

    Prospective evaluation of 69 patients. Ann Intern Med. Anand A. Prognostic factors of malignant mesothelioma of the pleura [letter]. Multimodality therapy for malignant mesothelioma based on a study of natural history. Am J Med. Diffuse malignant pleural mesothelioma in Glasgow. Br J Dis Chest.

    Computed tomography in the assessment of malignant mesothelioma of the pleura. Clin Radiol. Hillerdal G. Malignant mesothelioma review of published cases. Kawashima A, Libshitz HI. Malignant pleural mesothelioma: CT manifestations in 50 cases. Pleural fluid analysis in malignant mesothelioma. Prognostic implications. Pleural malignancies including mesothelioma. Curr Opin Pulm Med. Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability. The role of computed tomography scanning in the initial assessment and the follow-up of malignant pleural mesothelioma.

    J Thorac Cardiovasc Surg.

    Malignant Mesothelioma

    J Nucl Med. Herbert A, Gallagher PJ. Pleural biopsy in the diagnosis of malignant mesothelioma. The influence of the diagnostic technique on the histopathological diagnosis in malignant mesothelioma. Dejmek A. Methods to improve the diagnostic accuracy of malignant mesothelioma. Respir Med. Prognosis in malignant mesothelioma related to MIB 1 proliferation index and histological subtype. Hum Pathol. Diffuse malignant mesothelioma of the peritoneum following abdominal radiotherapy.

    Eur J Surg Oncol. Calretinin and other mesothelioma markers in synovial sarcoma: analysis of antigenic similarities and differences with malignant mesothelioma. Am J Surg Pathol. Asbestos exposure in malignant mesothelioma of the pleura: a survey of cases. Ind Health. Pathology of malignant mesothelioma. Malignant epithelioid mesothelioma: anti-mesothelial marker expression correlates with histological pattern.

    Suster S, Moran CA. Applications and limitations of immunohistochemistry in the diagnosis of malignant mesothelioma. Adv Anat Pathol. Potentiation of cisplatin and carboplatin cytotoxicity by amphotericin B in different human ovarian carcinoma and malignant peritoneal mesothelioma cells. Cancer Chemother Pharmacol. Surgical treatment of malignant pleural mesothelioma: a review. Accessed January 5, Kindler HL. Curr Treat Options Oncol. Huncharek M, Muscat J. Metastases in diffuse pleural mesothelioma: influence of histological type.

    Intracranial metastases from malignant pleural mesothelioma. Report of three autopsy cases and review of the literature. Arch Pathol Lab Med. A proposed new international TNM staging system for malignant pleural mesothelioma. From the International Mesothelioma Interest Group.

    Pathology of malignant mesothelioma.

    Laparoscopy: an important tool in the staging of malignant pleural mesothelioma. Ann Surg Oncol. Pleuropneumonectomy in the treatment of malignant pleural mesothelioma. Malignant mesothelioma of the pleural space. Oncology Huntingt. Surgically debulked malignant pleural mesothelioma: results and prognostic factors. Benard J. Bull Cancer. Material and Methods: Twenty tissue samples in paraffin blocks from the pathology department of Imam Reza Hospital in Tabriz whose pathology reports cited mesothelioma or metastatic lung adenocarcinomas, were included in the studies.

    These tissues were deemed appropriate for IHC in terms of tissue quality and quantity. They were studied and evaluated for pathological markers. Conclusion: The results of this study showed that CEA, CK7, TTF1, Calretinin and HBME1 are suitable criteria for differentiating between metastatic lung adenocarcinoma and mesothelioma, and can differentiate the mesothelioma and adenocarcinoma with high accuracy.

    Malignant mesothelioma: A ten years experience. Malignant pleural mesothelioma: clinicopathologic and survival characteristic in a consecutive series of 40 patients. Ann Thorac Cardiovasc Surg ;17 2 Multicentric study on malignant pleural mesothelioma in Turkey: clinicopathologic and survival characteristics of patients. Medical oncology ;29 5 The Lancet ; Immunohistochemical diagnosis of epithelioid mesothelioma: an update.

    Pathology Outlines - Mesothelioma - general

    Arch Pathol Lab Med ; 11 Immunohistochemical differential diagnosis between large cell neuroendocrine carcinoma and small cell carcinoma by tissue microarray analysis with a large antibody panel. Am J Clin Pathol ; Diagnostic utility of immunohistochemistry in distinguishing between epithelioid pleural mesotheliomas and breast carcinomas: a comparative study.

    Human pathology ;45 7 Determination of primary site by examination of cancer cells in body fluids.